Metabolic Advanced is a dietary supplement that's claimed to support a healthy metabolism, increase energy, encourage weight loss, help digestion, and sleep, and even improve mood.
Metabolic Advanced was developed by Dr. Steven Gundry, a pediatric heart surgeon with more than 30 years of experience in medicine.
Gundry is the director of the International Heart and Lung Institute located in Palm Springs.
He is also both the director and founder of the Center for Restorative Medicine, with locations in Santa Barbara and Palm Springs.
Metabolic Advanced Ingredients
Zinc is what’s known as an essential trace element because your body requires it for certain processes, but only in small amounts.
It's a key nutrient for immune functions, healing of wounds, some thyroid functions, blood clotting, and night vision. It is naturally found in fish, poultry, and red meat.
It shows promise in shortening the length of some viruses, but more study needs to be done to verify this.
There are also popular uses of zinc in fighting acne, in treating burns, in helping with the symptoms of ADHD, and in lowering blood sugar in those with diabetes, but there is not enough clinical evidence to support these claims.
Zinc may also make certain anti-depressants work better, but this has not been firmly established by clinical study.
What has been established for zinc is that it does not seem to increase recovery time for COVID-19, help with hair loss, help those who suffer from cystic fibrosis or HIV/AIDS, reduce the risk of developing prostate cancer, or decrease inflammation in patients with inflammatory bowel disease (IBD).
Selenium is an essential trace mineral like zinc. It is found in foods like Brazil nuts, eggs, breads, poultry, organ meats, and seafood.
People often use selenium to treat high blood pressure, to decrease cholesterol and to deal with symptoms of taking cholesterol medications, and to reduce risks of prostate cancer, but there is not sufficient scientific data to back these claims.
Chromium is another essential trace mineral. It is commonly used for high cholesterol, and polycystic ovary syndrome (PCOS), but there is little scientific data to back up these claims.
It's also used in lowering blood sugar in those with diabetes, but the clinical results have so far been conflicting on this issue, and it does not seem to help those with pre-diabetes or insulin resistance.
Although chromium is often added as a weight-loss ingredient in supplements, it is not clear if it actually helps people lose weight.
Cinnamon bark has been used as a spice for thousands of years. It does show promise in helping lower both blood sugar in those that have diabetes and in lowering cholesterol, but more clinical research is needed to verify these claims.
It has also been popular in weight loss formulas for the past several years, but claims that cinnamon bark can help you lose weight have not been proven in laboratory trials.
While cinnamon may exhibit anti-inflammatory and antioxidant properties, it has not been verified exactly what effect this may have on the human body.
Don’t be lured into thinking that cinnamon is harmless because it’s on your spice rack – see the side effects and interactions below.
Berberine HCI is a chemical substance found in plants like goldenseal, tree turmeric, and European barberry. It has been used medicinally for thousands of years in the traditional medicine of certain parts of Asia.
It shows promise in treating some heart conditions, and lowering cholesterol, as well as lowering blood sugar in those with diabetes, but more clinical research is needed to verify these results.
It’s also used commonly for high blood pressure, liver issues, and canker sores, but this hasn’t been proven in laboratory studies.
It’s also been suggested as a treatment for polycystic ovary syndrome (PCOS), but there isn’t sufficient data to support this claim.
Turmeric has been touted for a number of years as an anti-inflammatory due to a chemical called curcumin, and it does show promise in decreasing pain and swelling, but more scientific data is needed to verify these results and what impact turmeric would have on diseases such as osteoarthritis.
Turmeric shows promise in reducing hay fever symptoms and in easing depression in patients already on an antidepressant, but more data is needed to confirm this.
Don’t confuse turmeric with goldenseal, zedoary, or Javanese turmeric root – these are unrelated plants.
Black pepper, another ingredient right off everyone’s spice rack contains a chemical called peperine, which is said to increase turmeric absorption by some 2000 percent.
This may seem like an amazing attribute, but take into account that it may increase the adverse effects of turmeric just as it may increase the benefits.
Potential Side Effects
Zinc may cause nausea, abdominal pain, and upset stomach. Doses of zinc greater than 10 grams may be fatal.
Long-term alcoholism may reduce your body’s ability to absorb zinc.
Do not take zinc if you are taking quinolone antibiotics, tetracycline antibiotics, cisplatin, penicillamine, Keflex, Norvir, are taking medication for HIV or AIDS, amiloride, or atazanavir.
Selenium - can cause headache, skin rash, stomach pain, nausea, vomiting, fatigue, hair loss, and weight loss.
Do not take selenium if you have an autoimmune disease as this may stimulate your nervous system and make symptoms worse.
Selenium can also worsen hypothyroidism, particularly in those with iodine deficiency. It can also decrease sperm mobility and cause certain skin cancers to return.
Selenium can also interfere with healing after surgery, so you should refrain from taking it at least two weeks prior to surgery.
Do not take selenium if you are pregnant or breastfeeding, or if you have kidney disease. Selenium can interact with blood clotting medication, niacin, birth control pills, and barbiturates.
Chromium - can cause skin rashes, dizziness, headaches, mood changes, nausea, impaired judgement and thinking, and problems with coordination.
Do not take chromium if you have depression, anxiety, or schizophrenia. If you have a chromate or leather contact allergy, kidney disease, or liver disease you should also avoid taking chromium.
Consult with a physician before taking chromium if you have diabetes.
Chromium can interact with Synthroid, diabetes medications, NSAIDS and aspirin.
Cinnamon Bark - Do not take cinnamon bark if you have liver issues or diabetes. Do not take cinnamon bark if you have an allergy to the plant Peru balsam. Cinnamon may cause upset stomach, drowsiness, and skin rashes.
Berberine HCI - Do not take berberine HCI if you are pregnant as it may cause brain damage to the unborn fetus. Do not give berberine HCI to children. Do not take berberine HCI if you are breastfeeding.
Berberine may cause upset stomach, diarrhea, gas, and constipation.
Berberine can interact with cyclosporine, blood clotting medications, diabetes medications, blood pressure medications, dextromethorphan (such as Robitussin DM), losartan, midazolam, pentobarbital, tacrolimus, and metformin.
Turmeric - can cause nausea, diarrhea, dizziness, and upset stomach. Do not take a turmeric supplement if you are pregnant or breastfeeding.
Turmeric can worsen symptoms if you have issues with your gallbladder. Do not take turmeric if you have a bleeding disorder, iron deficiency, liver disease, breast cancer, uterine cancer, ovarian cancer, uterine fibroids, or endometriosis.
Turmeric may lessen sperm motility and decrease testosterone. Do not take turmeric within two weeks of any planned surgery as it may affect the healing process.
Turmeric may interact with warfarin, some cancer drugs, amlodipine, estrogen, norfloxacin, p-glycoprotein substrates, paclitaxel, and glyburide.
Black Pepper - Do not take a black pepper supplement if you are pregnant or are breastfeeding. Do not take a pepper supplement if you have a bleeding disorder or plan to have surgery within 2 weeks.
Pepper supplements can interact with lithium, p-glycoprotein substrates, phenytoin, propranolol, rifampin, theophylline, anticoagulants, diabetes medications, cyclosporine, nevirapine, pentobarbital, atorvastatin, carbamazepine, and amoxicillin.
How to Use Metabolic Advanced
The dose is one serving twice a day – once in the morning and once at night.
Cost and Price Plans
One bottle is $49.95. Three bottles cost $134.85 with free shipping. Six bottles cost $235.00 with free shipping.
Customer service may be reached at (800) 852-0477. No hours were listed.
All Gundry MD products come with a 90 day money back guarantee. If you are unhappy for any reason or are not experiencing any of the advertised benefits you can reach out to a representative to initiate a return/refund.
Online Customer Reviews/Complaints
The company website publishes only positive reviews of the product. However, if you search around independent review sites you can find more complaints for the company.
While the BBB rates the company highly there are over two hundred complaints on that platform.
It is a positive sign that Gundry MD’s customer service team seeks out and replies to negative online reviews, offering unhappy customers refunds or product exchanges.
Where to Buy?
This product can be purchased on the company website.
Competitors and Alternatives
Blood Sugar Support by GoBiotix is a similar formula with berberine, zinc, cinnamon, selenium, turmeric, black pepper, and chromium.
It has 4.3 out of 5 stars on Amazon, taken from 220 reviews. It is $23.97 for a one-month supply.
Is Metabolic Advanced Worth It?
First off, this should be avoided if you are pregnant or breastfeeding.
It is also a little worrying that it has so many ingredients that lower blood sugar, which could lead to excessive drops in blood sugar (hypoglycemia).
Given the many interactions and side effects, it’s surprising that this was formulated by a physician.
We would recommend consulting with your physician before taking this supplement to avoid any interactions and make sure that it would be beneficial to your current needs.
If you have any experience with Gundry MD Metabolic Advanced, please leave your reviews below.
|ZINC: Overview, Uses, Side Effects, Reviews (webmd.com)
Zinc Uses, Side Effects & Warnings - Drugs.com
Zinc | Memorial Sloan Kettering Cancer Center (mskcc.org)
SELENIUM: Overview, Uses, Interactions (webmd.com)
Selenium Uses, Side Effects & Warnings - Drugs.com
Selenium Supplement - Description and Brand Names - Mayo Clinic
Nutritional deficiency of selenium secondary to weight loss (bariatric) surgery associated with life-threatening cardiomyopathy - PubMed (nih.gov)
CHROMIUM: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (webmd.com)
Chromium Uses, Benefits & Side Effects - Drugs.com
Chromium Supplement - Description and Brand Names - Mayo Clinic
Diabetes treatment: Can cinnamon lower blood sugar? - Mayo Clinic
Cinnamon Uses, Benefits & Side Effects - Drugs.com Herbal Database
|Berberine: Are There Health Benefits? (webmd.com)
BERBERINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (webmd.com)
Berberine: Benefits, how to use, side effects, and warnings (medicalnewstoday.com)
TURMERIC: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (webmd.com)
Turmeric: Health Benefits, Nutrients per Serving, Preparation Information, and More (webmd.com)
Turmeric | Memorial Sloan Kettering Cancer Center (mskcc.org)
Black Pepper: Health Benefits, Nutrients per Serving, Preparation Information, and More (webmd.com)
BLACK PEPPER AND WHITE PEPPER: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (webmd.com)
Black Pepper: Health Benefits, Side Effects, Uses, Dose & Precautions (rxlist.com)
Black Pepper May Give You A Kick, But Don’t Count On It For Weight Loss | Mayo Clinic In The News
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